C Papp (2003). Chorionic Villus sampling. Ultrasound Review of Obstetrics and Gynecology, 3(4), 279-284. Retrieved February 21, 2008, from Research Library database. (Document ID: 548015861).

This article I found to be very helpful for my research on chorionic villus sampling. History and indications are first mentioned, detailing the popularity and process of this procedure. CVS has not always been the preferred choice of genetic diagnosis. It wasn’t until the 1970s when a chorionic tissue sample taken successfully as early as nine to ten weeks after conception did this test become well known. This time period is known as the first-trimester and by performing CVS this early in pregnancy emotional and physical strain on couples can be reduced. Sampling of the placenta may be performed one of two ways depending on the anatomical location of the chorion frondosum, either transcervically or transabdominally. Whichever location the sample is taken from, the catheter is guided by ultrasound to the chorion. At the beginning of the 1990s the use of CVS decreased because of a possible link between the test and fetal limb defects surfaced. Experiments and research were not conclusive on this relationship except for a possibility of CVS performed before the ten week traditional sampling. Nevertheless, chorionic villus sampling is on the rise because of advancements in molecular genetics. This now enables for a more precise diagnosis and the detection of many more disorders. Because of the low rate of complications associated with this test, chorionic villus is the preferred genetic procedure by many doctors and mothers.